RBFOX1, variants, traits, and what the research shows

RBFOX1 - what this gene does

Based on the variants catalogued here, RBFOX1 (634 variants on file) shows its strongest research associations with neurological traits, with additional signals linking it to cancer, rare disease, mental health, immune function, and kidney-related conditions.

Key takeaways

• The highest-magnitude variants in this gene cluster around neurological traits
• Cancer and rare disease associations appear among the top-ranked variants
• Mental health, immune, and kidney signals also appear in the published research
• Most associations derive from GWAS (genome-wide association studies - large scans for variants statistically linked to a trait) and carry population-level effect sizes
• Over 630 variants are on file; findings reflect group-level patterns, not individual predictions

Notable variants

The six variants reaching the highest recorded magnitude (5.50) divide between neurological and cancer associations. Five - rs1057521725, rs141919506, rs145351963, rs147306562, and rs376061440 - are each linked to neurological traits, while rs2093621567 carries a cancer association. Just below, three rare-disease variants - rs1064794750, rs2509828295, and rs2510618048 - reach magnitude 5.00. Among the published entries at magnitude 4.50, rs11865256 adds another neurological signal, while rs112896149 and rs11639759 contribute cancer associations.

Trait associations

Neurological traits represent the dominant theme, with five of the six top-magnitude variants in this category and an additional published neurological entry in rs11865256. Cancer associations are also well-represented, appearing at the highest tier through rs2093621567 and in published variants rs112896149 and rs11639759 - multiple variants pointing to the same broad trait domain lends additional weight to the general signal. Mental health associations appear through rs11077203 and rs13332522. Rarer domains each have at least one published variant: immune function through rs115434241, and kidney-related traits through rs11646886.

Evidence quality

With 634 variants catalogued and 61 carrying prior research summaries, this gene has a moderately large evidence footprint. The top-tier signals - magnitude 5.50 - are the highest-priority entries in the current dataset, but specific effect sizes (such as odds ratios or beta coefficients) and sample sizes are not available in the variant records provided here. The breadth of trait themes spanning six distinct domains warrants caution: associations scattered across neurological, cancer, rare disease, mental health, immune, and kidney categories could reflect genuine pleiotropy (where a single gene influences multiple biological pathways) or could indicate that some signals still await independent replication.

What this is NOT

These variants represent population-level statistical associations from research studies, not deterministic predictors of any outcome for any individual. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.