rs11076960 RBFOX1: brain sulcal depth
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Key takeaways
- rs11076960 is a common variant in RBFOX1 that influences brain sulcal depth
- The GWAS shows an effect size of 7.46 with p=9e-14 in about 33 thousand people
- GTEx data indicates increased expression of RBFOX1 in testis
Key takeaways
- rs11076960 is a common variant in RBFOX1 that influences brain sulcal depth
- The GWAS shows an effect size of 7.46 with p=9e-14 in about 33 thousand people [PMID 34910505]
- GTEx data indicates increased expression of RBFOX1 in testis [GTEx]
What the research says This variant is associated with vertex-wise sulcal depth, a measure of brain folding. The GWAS reports an effect size of 7.46, p=9e-14, in about 33 thousand individuals [PMID 34910505]. GTEx shows increased expression of RBFOX1 in the testis with a slope of +0.32 and p=1.8e-10 [GTEx].
Reported associations
- Brain sulcal depth: the variant is linked to deeper sulci, reported effect size 7.46, p=9e-14, in about 33 thousand individuals [PMID 34910505]
- Gene expression: increased RBFOX1 expression in testis, slope +0.32, p=1.8e-10 [GTEx]
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association.
Tissue-specific expression effects
- RBFOX1: increased expression in testis [GTEx Portal]
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11076960 do?
It is a common variant in RBFOX1 that influences brain sulcal depth and increases its expression in the testes.
Is this SNP linked to any disease?
The evidence shows it affects brain structure and gene expression but no direct disease link is reported.
Can I change my risk with lifestyle?
No lifestyle considerations are on file for this variant.