rs11646886 RBFOX1 bone mineral density urate interaction
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Key takeaways
- This SNP affects bone mineral density and serum urate levels
- The association is strong with a p-value of 1e-9 in about 4000 people
- It shows an interaction between the two traits
Key takeaways This SNP affects bone mineral density and serum urate levels The association is strong with a p-value of 1e-9 in about 4000 people It shows an interaction between the two traits
What the research says The GWAS Catalog reports that rs11646886-RBFOX1 is linked to an interaction between femur bone mineral density and serum urate levels with a reported effect size of 2.4 and a p-value of 1e-9 in about 4 thousand individuals PMID 34046847. This association suggests the variant may influence both bone density and uric acid levels.
Reported associations Femur bone mineral density is associated with this variant (effect size 2.4 p=1e-9) PMID 34046847. Serum urate levels is associated with this variant (effect size 2.4 p=1e-9) PMID 34046847.
Evidence quality The evidence comes from a single GWAS with about 4 thousand participants and a highly significant p-value of 1e-9 indicating strong association PMID 34046847. No replication studies are reported in the supplied data.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11646886 mean?
It is a genetic change in the RBFOX1 gene that has been linked to changes in bone mineral density and uric acid levels.
Is this variant dangerous?
The study shows it is associated with these traits but there is no evidence of disease risk or harm.
Can I test for this SNP?
Yes, many DNA testing services include RBFOX1 variants in their reports.