rs11639759 - RBFOX1: pancreatic cancer survival link
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Key takeaways
- This variant is linked to pancreatic cancer survival with a reported effect size of 1.56 and p=7e-6 in about 868 people.
- It reduces LINC01570 expression in the testis, a highly significant signal.
- The association is based on a genome-wide association study.
Key takeaways
- This variant is linked to pancreatic cancer survival with a reported effect size of 1.56 and p=7e-6 in about 868 people.
- It reduces expression of LINC01570 in the testis, a highly significant signal.
- The association is based on a genome-wide association study.
What the research says The GWAS Catalog reports that the T allele is associated with pancreatic cancer survival, showing a reported effect size of 1.56 and p=7e-6 in about 868 individuals [PMID 28470677]. GTEx expression data indicate that this variant reduces LINC01570 expression in the testis, a signal with p=2.7e-15 GTEx Portal.
Reported associations Pancreatic cancer survival - the T allele is linked to longer survival with a reported effect size of 1.56 and p=7e-6 in about 868 individuals [PMID 28470677]. LINC01570 expression - this variant reduces LINC01570 expression in the testis, a highly significant signal GTEx Portal.
Evidence quality The evidence comes from a single genome-wide association study of 868 individuals with an effect size of 1.56 and p=7e-6 for pancreatic cancer survival [PMID 28470677]. No replication studies are provided in the catalog, so the finding is not independently confirmed.
Tissue-specific expression effects
- LINC01570: reduced expression in testis GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11639759 mean?
It is a genetic change in RBFOX1 that has been linked to longer survival after pancreatic cancer and also lowers LINC01570 expression in the testis.
Is this variant common or rare?
The GWAS catalog reports it as a risk allele with an effect size of 1.56 and p=7e-6, indicating it is not extremely rare but has measurable impact.
Can I change my health by taking supplements?
There are no lifestyle recommendations for this variant; it does not affect diet or supplement use.