rs12447665 RBFOX1 and proliferative diabetic retinopathy
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is linked to higher risk of proliferative diabetic retinopathy
- The effect size is 1.83 with p=2e-6
- It was studied in about 4000 people
Key takeaways This variant is linked to higher risk of proliferative diabetic retinopathy. The effect size is 1.83 with p=2e-6. It was studied in about 4000 people.
What the research says This variant is associated with proliferative diabetic retinopathy versus no disease, a reported effect size of 1.83 and p=2e-6 PMID 30487263. The study involved about 4 thousand individuals.
Reported associations Proliferative diabetic retinopathy This variant increases risk of proliferative diabetic retinopathy by a reported effect size of 1.83, p=2e-6 PMID 30487263.
Evidence quality The evidence comes from a genome-wide association study of about 4 thousand individuals PMID 30487263. The variant shows a strong association with proliferative diabetic retinopathy, p=2e-6, but no replication data are provided in the catalog.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12447665 mean?
It is a change in the RBFOX1 gene that has been associated with higher risk of proliferative diabetic retinopathy.
Is this variant common?
The study looked at about 4000 people and found it present in many, but exact frequency isn't given.
Can I get a test for this?
You can request a DNA analysis that includes rs12447665; the result will show if you carry the variant.