LINC02763, variants, traits, and what the research shows

LINC02763 - what this gene does

LINC02763 (Long Intergenic Non-Coding RNA 02763) is a long non-coding RNA gene - a region of DNA that is transcribed into RNA but does not encode a protein. Based on the variants catalogued at this locus, research has linked the gene to trait themes spanning neurological conditions, metabolic phenotypes, liver-related measures, musculoskeletal traits, and mental health.

Key takeaways

• This gene carries over 100 documented genetic variants, with the highest-magnitude signals touching neurological, metabolic, and liver traits.
• Four variants reach magnitude 4.50 - the top tier in the dataset - including neurological, metabolic, and liver-linked signals.
• Musculoskeletal associations appear across five separate variants, making it the most numerically represented theme among the lower-magnitude signals.
• Neurological signals recur across three independent variants, suggesting a relatively consistent connection to this trait domain.
• All associations are population-level statistics and are not predictive for any individual.

Notable variants

The four variants carrying the strongest signals each score at magnitude 4.50. rs10789907 is linked to neurological traits, rs186143467 to metabolic phenotypes, and rs67605007 to liver-related measures; rs117202086 also reaches this tier, though its specific trait annotation is not on file. Among the magnitude-2.20 variants, neurological signals recur at rs1001060 and rs4604926; musculoskeletal signals appear across rs10082586, rs11214269, rs11606786, rs144115184, and rs5794803; a mental-health association is recorded for rs11214218; and a nutrition-related signal appears at rs140488904.

Trait associations

The variant landscape at this locus spans five broad trait domains. Neurological phenotypes carry the strongest overall signal: rs10789907 (magnitude 4.50) leads the tier, with additional neurological associations at rs1001060 and rs4604926. The metabolic domain is anchored by rs186143467 (magnitude 4.50), while liver-related traits are tied to rs67605007 (magnitude 4.50). Musculoskeletal traits appear across the greatest number of lower-magnitude variants: rs10082586, rs11214269, rs11606786, rs144115184, and rs5794803 all carry signals in this category. Single-variant signals extend the gene's profile into mental health (rs11214218) and nutrition (rs140488904).

Evidence quality

This gene hosts 102 catalogued variants, of which 35 have associated research summaries; the current dataset includes editorial detail on 20 variants. The neurological and musculoskeletal themes each appear across multiple independent variants - three and five respectively - which provides modest cross-variant support relative to the singleton metabolic and liver signals. Most signals in this dataset are expected to derive from GWAS (genome-wide association studies - large population-level scans that identify variants statistically associated with a trait); individual effect sizes, odds ratios, and sample sizes are not available in the current summary data, so the practical magnitude of these associations cannot be fully characterised here. Findings should be treated as preliminary signals pending fuller replication data.

What this is NOT

The variants catalogued here are population-level statistical signals derived from studies of large groups, and they are not deterministic predictors of any trait, condition, or health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.