rs11214218 - schizophrenia risk SNP

Key takeaways

• This SNP is linked to schizophrenia risk with a small effect size.
• It increases expression of the gene in nerve tissue and colon tissue.
• The association was found in a large GWAS study.

What the research says The GWAS Catalog reports that the G allele of rs11214218 is associated with schizophrenia risk, with an effect size of 0.96 and a p-value of 6e-8 in about 175 thousand individuals [PMID 35396580]. GTEx data shows that the LINC02762 gene expression increases in nerve tissue and colon tissue [GTEx Portal].

Reported associations Schizophrenia: the G allele is associated with higher risk, effect size 0.96 p=6e-8 [PMID 35396580].

Evidence quality The GWAS used about 175 thousand individuals, yielding a small effect size of 0.96 and a highly significant p-value of 6e-8 [PMID 35396580]. No other studies are cited for this variant.

Tissue-specific expression effects

• LINC02762: increased expression in nerve tissue and colon tissue [GTEx Portal].

Last lifestyle considerations on file for this variant.