Expressive

rs11214269 (LINC02763): linked to lower heel bone mineral density

Key takeaways

  • rs11214269 is linked to lower heel bone mineral density with a small effect in large GWAS
  • The variant lies on the LINC02763 region
  • No known tissue-specific expression effects reported

Key takeaways

  • rs11214269 is linked to lower heel bone mineral density with a small effect in large GWAS
  • The variant lies on the LINC02763 region
  • No known tissue-specific expression effects reported

What the research says The rs11214269 variant on LINC02763 is associated with lower heel bone mineral density a reported effect size of 0.018 p=9e-19 PMID 30048462.

Reported associations

  • Heel bone mineral density this variant is associated with lower heel bone mineral density a reported effect size of 0.018 p=9e-19 [PMID 30048462].

Evidence quality The supplied study is a genome-wide association study involving about 394 thousand individuals reporting an effect size of 0.018 and p=9e-19 with no conflicting findings.

Tissue-specific expression effects

  • NCAM1: reduced expression in Nerve_Tibial GTEx Portal.

No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • bone mineral density screening Moderate

    rs11214269 associates with heel bone mineral density; assessment stratifies fracture risk and osteoporosis prevention needs.

    Discuss baseline DXA screening with healthcare provider if age 50 or older or additional risk factors present.

Frequently asked questions

What does rs11214269 mean?

It is a genetic variant on the LINC02763 region linked to lower heel bone mineral density based on a large GWAS study.

Is this variant harmful?

The evidence shows an association with lower heel bone mineral density but no direct health risk; it does not cause disease.

Can I change my DNA to fix this?

No, the variant is common and its effect is small; lifestyle changes are not linked to it.