rs10789907 (LINC02763): cognitive ability link
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Key takeaways
- This variant is linked to general cognitive ability with a small effect size.
- It reduces LINC02763 expression in brain tissue.
- The gene also shows lower levels in pancreas and higher in muscle.
Key takeaways
- This variant is linked to general cognitive ability with a small effect size.
- It reduces LINC02763 expression in brain tissue.
- The gene also shows lower levels in pancreas and higher in muscle.
What the research says The GWAS Catalog reports that rs10789907 is associated with general cognitive ability, showing a reported effect size of 5.34 and p=9e-8 in about 300 thousand individuals [PMID 29844566]. GTEx data indicate that the LINC02763 gene is expressed lower in brain basal ganglia tissue, with a slope of -0.21 and p=6.7e-5 [GTEx].
Reported associations
- General cognitive ability: the variant is linked to general cognitive ability with a reported effect size of 5.34 p=9e-8 in about 300 thousand individuals [PMID 29844566].
- Brain basal ganglia gene expression: the variant reduces LINC02763 expression in brain basal ganglia tissue, with a slope of -0.21 and p=6.7e-5 GTEx Portal.
Evidence quality The GWAS study used about 300 thousand individuals and reported a strong association with general cognitive ability, p=9e-8. The GTEx expression data are from 953 donors within the cis window, showing a significant reduction in LINC02763 expression in brain basal ganglia tissue, p=6.7e-5. No conflicting findings were reported.
Tissue-specific expression effects
- LINC02763: reduced expression in brain basal ganglia tissue GTEx Portal.
- NCAM1: reduced expression in pancreas and increased expression in muscle skeletal tissue GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10789907 mean?
rs10789907 is a genetic variant at the LINC02763 locus that has been associated with general cognitive ability and influences expression of the LINC02763 gene in brain tissue.
Is this variant linked to disease?
The evidence does not indicate any direct link to disease; it is only associated with cognitive traits and gene expression changes.
Can I change my risk?
No, the variant does not cause disease or health outcomes on its own.