rs10082586 (LINC02763): Bone Density & NCAM1 Protein

Key takeaways

• Strong statistical association with bone mineral density in large population cohorts
• Linked to variations in NCAM1 protein levels in tens of thousands of participants
• Shows tissue-specific expression effects in nerves, arteries, pancreas, and thyroid
• Functions as a non-coding regulatory region influencing nearby gene activity

What the research says Genome-wide association studies identify this variant as significantly correlated with bone mineral density measurements across a cohort of approximately 141 thousand individuals PMID 37500982. Independent analysis also reports a statistical link to NCAM1 protein levels, with a reported effect size of 0.081 and a p-value of 2e-56 in roughly 47 thousand participants PMID 39789286.

Reported associations

• Bone mineral density mean: The variant shows a highly significant statistical association with bone mineral density measurements, reaching a p-value of 8e-17 in a sample of about 141 thousand individuals PMID 37500982.
• NCAM1 protein levels: Research documents a statistical association with circulating NCAM1 protein concentrations, reporting an effect size of 0.081 and a p-value of 2e-56 in approximately 47 thousand people, with the G allele noted as the effect allele PMID 39789286.

Evidence quality The available data draws from large-scale cohorts totaling over 188 thousand individuals, which provides substantial statistical power and reduces the likelihood of false-positive findings. Both reported associations reach genome-wide significance thresholds, indicating robust replication potential within the provided datasets. While the variant is anchored to the LINC02763 locus, the supplied genomic data highlights regulatory effects on neighboring genes including LINC02762, NCAM1, and DLAT. Because this variant resides in a non-coding region, the supplied studies frame the findings as statistical correlations rather than established causal pathways. The evidence does not currently resolve whether the observed links operate through direct molecular mechanisms or secondary physiological cascades.

Tissue-specific expression effects

• LINC02762: Increased expression in the tibial nerve and pancreas, with reduced expression in the tibial artery GTEx Portal.
• NCAM1: Increased expression in the tibial nerve GTEx Portal.
• DLAT: Reduced expression in the thyroid GTEx Portal.

Lifestyle considerations No lifestyle considerations on file for this variant.