LINGO2, variants, traits, and what the research shows

LINGO2 - what this gene does

Variants near LINGO2 have been identified in GWAS - genome-wide association studies, which scan many people's genomes for variants statistically associated with a trait - with annotations spanning mental health, liver-related measures, cardiovascular traits, cancer risk, and immune function. The variant catalog alone places this gene at the intersection of several distinct biological domains.

Key takeaways

• Mental health is the most represented trait theme, with eight variants in this gene carrying that annotation
• Liver, cardiovascular, cancer, and immune traits each appear in at least one catalogued variant
• All listed variants carry a moderate-effect score consistent with typical GWAS signals
• 157 variants are on file for this gene, with 35 carrying published research context
• These are population-level statistical associations, not predictions for any individual

Notable variants

Seven variants have published research pages, representing the best-evidenced signals in this catalog: rs10812851, rs10968719, rs12344656, and rs12348435 all carry mental health annotations; rs10968541 is annotated to liver traits; rs10968750 to cardiovascular traits; and rs117927012 to cancer. Four additional mental health signals - rs1402796, rs1438479, rs58271251, and rs58662928 - extend the mental health cluster, while rs188729037 adds a second cancer signal.

Trait associations

Mental health is the dominant theme, with eight variants - rs10812851, rs10968719, rs12344656, rs12348435, rs1402796, rs1438479, rs58271251, and rs58662928 - carrying that annotation; multiple variants converging on the same trait category is consistent with an actively investigated genomic region. Liver-related traits appear at rs10968541 and rs12555559, cardiovascular traits at rs10968750, and cancer associations at rs117927012 and rs188729037. The catalog also includes immune-function (rs12683261), neurological (rs148382232), and rare-disease (rs16912278, rs184726399) annotations.

Evidence quality

All twenty variants listed here share a uniform magnitude score of 4.50, consistent with moderate-effect GWAS associations. Of the 157 total variants on file, 35 carry published research context; specific odds ratios, beta coefficients, and sample sizes are not available in this compilation. The seven variants with published pages - rs10812851, rs10968541, rs10968719, rs10968750, rs117927012, rs12344656, and rs12348435 - represent the best-evidenced signals in this set. The breadth of trait themes across neuropsychiatric, metabolic, oncological, and immunological domains is notable; such multi-domain signals can reflect pleiotropy (one gene genuinely influencing multiple independent biological pathways) or linkage disequilibrium (variants statistically co-inherited with nearby functional loci rather than being individually causal). Replication status and cohort breadth cannot be confirmed without the underlying study metadata.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies and are not deterministic predictors of health outcomes for any individual. Nothing on this page constitutes medical advice, diagnosis, or a recommendation for any action.