rs10968750 - LINGO2

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension. - GeroScience (2020) · Nazarian A, Arbeev KG, Yashkin AP, Kulminski AM · PubMed 31055733

  Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by the interplay of multiple genetic and non-genetic factors. Hypertension is one of the AD risk factors that has been linked to underlying pathological changes like senile plaques and neurofibrillary tangles formation as well as hippocampal atrophy. In this study, we investigated the differences in the genetic architecture of AD between hypertensive and non-hypertensive subjects in four independent cohorts. Our genome-wide association analyses revealed significant associations of 15 novel potentially AD-associated polymorphisms (P < 5E-06) that were located outside the chromosome 19q13 region and were significant either in hypertensive or non-hypertensive groups. The closest genes to 14 polymorphisms were not

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