rs10968719 LINGO2 neuroticism and thyroid expression
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Key takeaways
- LINGO2 is linked to neuroticism traits
- The T allele reduces LINGO2 expression in the thyroid
- This association was found in a large GWAS of about 449 thousand people
Key takeaways
- LINGO2 is linked to neuroticism traits.
- The T allele reduces LINGO2 expression in the thyroid.
- This association was found in a large GWAS of about 449 thousand people.
What the research says A genome-wide association study found that the T allele of rs10968719 is linked to higher neuroticism scores [PMID 29942085]. The variant reduces LINGO2 expression in the thyroid.
Reported associations Neuroticism: the T allele is associated with higher scores, effect size 5.46 p=5e-8 in about 449 thousand individuals [PMID 29942085].
Evidence quality The GWAS used a sample of roughly 449 thousand participants and reported a significant association with neuroticism at p=5e-8. No conflicting findings were noted.
Tissue-specific expression effects
- LINGO2: reduced expression in thyroid GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
Is rs10968719 linked to neuroticism?
Yes it is associated with higher scores in a large GWAS.
Does rs10968719 affect thyroid function?
It reduces LINGO2 expression in the thyroid according to GTEx data.
Can this variant cause disease?
The evidence does not link it to any known disease; it is only associated with neuroticism traits.