rs12344656 (LINGO2): linked to neuroticism
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Key takeaways
- The rs12344656 variant is linked to higher neuroticism scores.
- It reduces LINGO2 expression in the thyroid gland.
- The association was found in a large GWAS of about 449 thousand people.
Key takeaways
- The rs12344656 variant is linked to higher neuroticism scores.
- It reduces LINGO2 expression in the thyroid gland.
- The association was found in a large GWAS of about 449 thousand people.
What the research says The GWAS catalog reports that the A allele of rs12344656 is associated with higher neuroticism scores, a reported effect size of 7.28, p=3e-13 [PMID 29942085]. GTEx data shows this variant reduces LINGO2 expression in the thyroid gland GTEx Portal.
Reported associations
- Neuroticism: The A allele is linked to higher neuroticism scores with a reported effect size of 7.28 and p=3e-13 [PMID 29942085].
- Thyroid gene expression: The A allele reduces LINGO2 expression in the thyroid gland, with a reported slope of -0.14 and p=1.6e-6 GTEx Portal.
Evidence quality The GWAS used about 449 thousand individuals, yielding a highly significant p-value of 3e-13. The expression effect is from GTEx v11 with 953 donors and a small slope magnitude of -0.14 in the thyroid [PMID 29942085].
Tissue-specific expression effects
- LINGO2: reduced expression in thyroid GTEx Portal.
No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to higher neuroticism Moderate
LINGO2 rs12344656 A allele shows significant association with neuroticism (GWAS p=3.00e-13, n=449484), a trait linked to increased anxiety and depression risk
Screening
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mental health screening for anxiety and depression Moderate
Higher neuroticism from rs12344656 A allele associated with increased risk of anxiety and depression; baseline evaluation recommended for at-risk individuals
Frequently asked questions
What does the rs12344656 LINGO2 variant do?
It is linked to higher neuroticism scores and reduces LINGO2 expression in the thyroid gland.
Is this variant related to anxiety?
Yes, studies show the A allele correlates with higher neuroticism which often includes anxiety feelings.
Can I change my behavior because of this gene?
No specific lifestyle changes are recommended for this common variant as it does not affect health outcomes.