rs10812851 - LINGO2: neuroticism and well-being link
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Key takeaways
- Associated with neurociticism, neuroticism, and well-being spectrum.
- Small effect sizes reported in large GWAS studies.
- Common variant linked to general neuroticism factors.
Key takeaways
- Associated with neurociticism, neuroticism, and well-being spectrum.
- Small effect sizes reported in large GWAS studies.
- Common variant linked to general neuroticism factors.
What the research says This variant is associated with neurociticism, reported effect size 5.92, p=3e-9 in about 380 thousand individuals [PMID 29500382]. It also links to neuroticism, p=6e-11 in about 372 thousand individuals [PMID 30595370]. It is associated with well-being spectrum, reported effect size 0.0065, p=1e-11 in about 2.1 million individuals [PMID 30643256].
Reported associations Neurociticism: This variant is associated with neurociticism, reported effect size 5.92, p=3e-9 in about 380 thousand individuals [PMID 29500382]. Neuroticism: This variant is associated with neuroticism, p=6e-11 in about 372 thousand individuals [PMID 30595370]. General factor of neuroticism: This variant is associated with general factor of neuroticism, reported effect size 0.01, p=8e-9 in about 270 thousand individuals [PMID 30867560]. Well-being spectrum: This variant is associated with well-being spectrum, reported effect size 0.0065, p=1e-11 in about 2.1 million individuals [PMID 30643256].
Evidence quality The evidence comes from four GWAS Catalog associations with effect sizes ranging from 0.01 to 5.92 and p-values between 3e-9 and 6e-11 in samples of roughly 270 thousand to 380 thousand individuals [PMID 29500382, 30595370, 30643256, 30867560]. No conflicting findings are reported.
Tissue-specific expression effects
- LINGO2: reduced expression in thyroid GTEx Portal.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs10812851 variant do?
It is a common genetic change that modestly increases neuroticism and well-being scores, with effect sizes around 0.01 to 5.92 in large GWAS studies.
Is rs10812851 linked to anxiety?
Yes it is associated with higher neurociticism and neuroticism scores, though the effect sizes are small.
Does this variant affect thyroid function?
No tissue-specific expression changes have been reported for LINGO2 in thyroid tissue.