TENM2, variants, traits, and what the research shows

TENM2 - what this gene does

Variants catalogued in TENM2 span trait categories including cancer, liver conditions, immune function, neurological traits, mental health, and rare disease.

Key takeaways

• TENM2 has over 300 catalogued variants, with the highest-evidenced signals touching cancer, liver, immune, neurological, and mental health trait categories
• Cancer associations appear across at least three top-tier variants, and liver associations across two - repeated signals across independent variants can indicate a more robust finding
• Immune-related variants appear in at least three separate research entries for this gene
• Mental health and neurological trait associations are also represented among the highest-magnitude findings
• All associations described here are population-level statistical signals, not predictions for any single individual

Notable variants

Among the highest-magnitude variants on file, several carry specific trait annotations. In the cancer category, rs112964125 and rs114329017 both have published research pages and share the top evidence tier; rs577665147 is also annotated for cancer. Liver-linked signals appear in rs116264057 and rs116675619, both with published pages. Immune function is flagged across rs181809880, rs536132913, and rs72831309. Mental health associations are noted for rs68057166 and rs74757231; a neurological association appears in rs6555748; and a rare disease phenotype is linked to rs147208935.

Trait associations

The research record spans six categories. Cancer is the most represented theme, with at least three high-magnitude variants - rs112964125, rs114329017, and rs577665147 - flagged in genome-wide association studies (GWAS - studies that scan large numbers of people's genomes for variants statistically associated with a trait). Liver conditions appear in two variants with published curation: rs116264057 and rs116675619. Immune function is represented by three variants: rs181809880, rs536132913, and rs72831309. Mental health associations appear in rs68057166 and rs74757231; a neurological trait link in rs6555748; and a rare disease phenotype in rs147208935. Several additional top-tier variants - including rs10061819, rs113221192, rs13358864, rs141001162, rs17068133, rs17068792, rs6885116, and rs72830077 - are catalogued at the same evidence tier without a specific trait label currently assigned.

Evidence quality

All 20 top-tier variants listed here share an identical magnitude score of 4.50, indicating they sit at the same tier of evidence strength rather than a single dominant signal standing apart from the rest. The gene has 304 total variants on file, of which 37 carry prior research summaries - the large majority of catalogued variants are earlier-stage findings awaiting fuller editorial review. Cancer and liver trait associations have published SNP pages (rs112964125, rs114329017, rs116264057, rs116675619), indicating a higher level of curation for those signals; however, specific effect sizes, odds ratios, and cohort sample sizes are not available in the current input data, so individual associations cannot be ranked further at this time. The breadth of trait categories - spanning six distinct domains - warrants caution about inferring a single coherent biological pathway from the available signal.

What this is NOT

These variants represent population-level statistical associations identified through GWAS and related research - they are not deterministic predictors of any trait or condition for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.