rs113221192 (TENM2): fracture risk
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Key takeaways
- The rs113221192 TENM2 variant is linked to a higher chance of rib and thoracic spine fractures
- The effect size is 1.57 with p=2e-8 in about 75 thousand people
- This association comes from a single GWAS catalog study
Key takeaways
- The rs113221192 TENM2 variant is linked to a higher chance of rib and thoracic spine fractures
- The effect size is 1.57 with p=2e-8 in about 75 thousand people
- This association comes from a single GWAS catalog study
What the research says The rs113221192 TENM2 variant is associated with ICD10 S22 fracture of rib(s) sternum and thoracic spine PMID 37601966
Reported associations
- ICD10 S22 fracture of rib(s) sternum and thoracic spine: the variant increases risk with a reported effect size of 1.57 p=2e-8 in about 75 thousand individuals PMID 37601966 Evidence quality The evidence is limited to a single GWAS catalog association in about 75 thousand individuals with effect size 1.57 p=2e-8 and no replication reported. No lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs113221192 TENM2 variant do?
It is associated with a higher risk of rib and thoracic spine fractures based on a large genetic study.
Is this variant linked to osteoporosis?
The data do not show any connection to bone density or osteoporosis.
Can I get a test for this SNP?
Yes it can be detected in DNA tests that include TENM2 variants but the clinical significance is limited.