PPP1R3B-DT, variants, traits, and what the research shows

PPP1R3B-DT - what this gene does

PPP1R3B-DT (PPP1R3B divergent transcript) is a gene locus whose catalogued variants show associations spanning cardiovascular, mental health, kidney, liver, metabolic, immune, and musculoskeletal trait categories in GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically associated with a trait) research.

Key takeaways

• Variants here have been linked to cardiovascular, kidney, mental health, and metabolic traits in population-level genetic research.
• The highest-magnitude variants on file all score 4.50, indicating strong statistical associations in the underlying studies.
• Kidney and mental health categories each show two independent variants pointing to the same domain, offering some within-gene replication of those signals.
• 263 total variants are catalogued in this gene, with multiple having published research pages.
• All associations are population-level GWAS signals - not deterministic predictors for any individual.

Notable variants

The strongest on-file variants all score at magnitude 4.50. Among those with trait labels: rs1011158 is linked to cardiovascular traits; rs2054349 and rs35847492 both carry mental health associations; rs393155 and rs4240624 are associated with kidney phenotypes; rs6984305 is linked to liver traits; rs7841407 carries a cancer-related signal; and rs983311 is associated with metabolic traits. Several additional magnitude-4.50 variants - rs10094141, rs10099338, rs1011159, rs13274716, rs138684226, rs6984193, rs74463341, and rs77299709 - have published or pending pages with trait detail not yet available in this dataset.

Trait associations

Cardiovascular traits are represented by rs1011158. Mental health phenotypes appear across two independent variants, rs2054349 and rs35847492, providing some replication of that signal within this locus. Kidney-related associations are similarly supported by two variants, rs393155 and rs4240624. Liver associations are noted for rs6984305, a cancer-related signal appears in rs7841407, and metabolic traits appear in both rs983311 and rs435581. Lower-magnitude signals (2.80) include an immune association in rs330048 and a musculoskeletal association in rs330071.

Evidence quality

The highest-magnitude variants on file (4.50) span multiple trait categories and include several with published editorial pages - rs10094141, rs10099338, rs1011158, rs1011159, and rs10087406 - suggesting a higher confidence tier for those entries. Kidney and mental health categories each show two independent variants pointing to the same domain, which offers a degree of within-gene replication. Detailed effect sizes (such as odds ratios or beta coefficients) and cohort sample sizes are not available in the current dataset for most entries, limiting precise characterization of association strength. The lower-magnitude signals (rs330048, rs330071, and rs435581 at 2.80, and rs10087406 at 2.20) may reflect smaller study sizes or less-replicated findings and should be interpreted with additional caution.

What this is NOT

These variants are population-level statistical signals identified in GWAS research; they are not deterministic predictors of any health outcome for any individual. This content is informational only - we do not prescribe, diagnose, or advise any course of action.