rs10094141 (PPP1R3B): cortical surface area increase
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Key takeaways
- The rs10094141 variant is linked to higher cortical surface area
- It shows a strong genetic signal with p=1e-7 in over 33 thousand people
- The allele A is associated with the increase
Key takeaways
- The rs10094141 variant is linked to higher cortical surface area
- It shows a strong genetic signal with p=1e-7 in over 33 thousand people
- The allele A is associated with the increase
What the research says The rs10094141 variant in PPP1R3B is linked to higher cortical surface area with a reported effect size of 10.77 p=1e-7 in about 33 thousand individuals [PMID 32193296].
Reported associations Cortical surface area: the variant increases cortical surface area with a reported effect size of 10.77 p=1e-7 in about 33 thousand individuals [PMID 32193296].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association [PMID 32193296]. The evidence is strong with large sample size and low p-value but no replication data.
Tissue-specific expression effects
- PPP1R3B: reduced expression in testis, increased expression in pituitary, brain cortex, cells cultured fibroblasts, esophagus mucosa, visceral omentum GTEx Portal
- PRAG1: reduced expression in thyroid GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10094141 mean?
It is a single nucleotide change in the PPP1R3B gene that has been linked to higher cortical surface area.
Is this variant common or rare?
The risk allele A occurs at moderate frequency and the effect is significant but not rare.
Does it affect other traits?
It also influences expression of PPP1R3B in several tissues such as testis, pituitary and brain cortex.