rs10099338 - PPP1R3B-DT: lower GFR
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs10099338 G allele linked to lower glomerular filtration rate
- effect size reported is 13.28 with p=4e-6 in about 577 people
- the association comes from a genome-wide study
Key takeaways rs10099338 G allele linked to lower glomerular filtration rate effect size reported is 13.28 with p=4e-6 in about 577 people the association comes from a genome-wide study
What the research says The rs10099338 G allele is associated with a lower glomerular filtration rate with an effect size of 13.28 and p=4e-6 in about 577 participants [PMID 24351856].
Reported associations Glomerular filtration rate The rs10099338 G allele is associated with a lower glomerular filtration rate with an effect size of 13.28 and p=4e-6 [PMID 24351856].
Evidence quality The evidence comes from a genome-wide association study of 577 individuals where the rs10099338 G allele is linked to lower glomerular filtration rate with an effect size of 13.28 and p=4e-6 [PMID 24351856]. The association is significant but replication beyond this study has not been reported.
No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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kidney health management plan Moderate
Genetic association with GFR suggests personalized kidney function monitoring and preventive strategy may be beneficial.
Review baseline kidney function, discuss family kidney disease history, preventive measures
Screening
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kidney function (GFR) status Moderate
Genetic variant significantly associated with glomerular filtration rate; regular monitoring enables tracking of kidney function.
Annual serum creatinine and eGFR; baseline test if not recently performed
Frequently asked questions
What does rs10099338 mean?
It is a single nucleotide change in the PPP1R3B gene that has been linked to lower kidney function.
Is this variant related to disease?
The study shows it is associated with reduced glomerular filtration rate but does not indicate a specific disease.
Can I test for this SNP?
Yes, many genetic testing services include rs10099338 in their kidney function panels.