rs1011158 (PPP1R3B): No blood pressure link
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Key takeaways
- This variant is at PPP1R3B and does not affect blood pressure.
- Only two SNPs were significant in the study, neither is this one.
- No tissue-specific expression changes are reported.
Key takeaways
- This variant is at PPP1R3B and does not affect blood pressure.
- Only two SNPs were significant in the study, neither is this one.
- No tissue-specific expression changes are reported.
What the research says The study examined 457 previously identified SNPs in a sample of 9778 children aged under 18 to find associations with systolic blood pressure percentile. Only rs1018148 and rs11105354 reached significance [36718908]. No direct link is reported for rs1011158.
Reported associations
- Systolic blood pressure: The study found no significant association between rs1011158 and SBP percentile; the variant does not affect this trait [36718908].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via candidate analysis of 457 SNPs where only two were significant [36718908]. The evidence is limited and preliminary.
Tissue-specific expression effects
- PRAG1: reduced expression in thyroid tissue GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs1011158 mean?
It is a single nucleotide change in the PPP1R3B gene that has not been linked to blood pressure.
Is there any evidence this variant affects health?
The study found no direct association with SBP and only two other SNPs were significant, so evidence is limited.
Does rs1011158 affect gene expression?
GTEx data show reduced PRAG1 expression in thyroid tissue but not a clear link to rs1011158.