Expressive

rs1018148 - FBN1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

  • Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418

    ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Sodium restriction for blood pressure management Moderate

    Dietary sodium reduction lowers systolic BP, especially important in individuals with genetic BP elevation

    Limit sodium intake to <2300 mg daily

Discuss with your doctor

  • FBN1-associated cardiovascular risk assessment Moderate

    rs1018148-A genotype increases systolic BP risk; medical counseling optimizes individualized prevention strategy

Exercise

  • Regular aerobic exercise for blood pressure management Moderate

    Aerobic exercise reduces systolic BP and vascular stiffness, counteracting FBN1-variant-associated BP elevation

    150 minutes moderate-intensity aerobic exercise per week

Screening

  • Annual blood pressure screening and monitoring High

    rs1018148-A allele increases systolic BP by ~0.43 mmHg per allele; early detection enables preventive intervention

    Annual screening; more frequent if elevated (>=120 mmHg)