NAV2, variants, traits, and what the research shows

NAV2 - what this gene does

NAV2 (Neuron Navigator 2, also known as RAINB1), located on chromosome 11, has variants on file spanning several trait categories: neurological conditions, mental health, cardiovascular traits, pharmacogenomics (how genetic variation influences an individual's response to medications), rare disease, liver, and vision. The available data does not include study-level mechanistic detail, so the following entry characterizes the gene through the trait themes its variants are associated with.

Key takeaways

• NAV2 variants are linked across neurological, cardiovascular, mental health, and rare disease trait categories
• The highest-magnitude signal in this gene is assigned to a rare disease category
• Three separate variants carry neurological trait labels, making it the most recurrent trait theme in the catalog
• Several variants are categorized under pharmacogenomics, pointing toward possible drug-response relevance
• Additional signals extend into liver and vision trait themes

Notable variants

The top-ranked variant by magnitude is rs548877132 (magnitude 5.50), assigned to the rare disease category - the single highest-magnitude signal in this gene's catalog. At magnitude 4.50, rs10766557 and rs10766558 both carry neurological trait labels, as does rs58906355. A mental health association appears at rs11025120, also at magnitude 4.50. Cardiovascular signals cluster at rs11605275 and rs12799264 (both magnitude 4.50). Pharmacogenomics associations appear at rs146425640 and rs188478854, each at magnitude 4.50. Liver and vision trait labels are carried by rs717015 and rs729999, respectively.

Trait associations

The neurological category is represented by three variants - rs10766557, rs10766558, and rs58906355 - making it the most recurrent trait theme on file. Cardiovascular associations appear at rs11605275 and rs12799264. A mental health signal is recorded at rs11025120, and pharmacogenomics trait labels appear at rs146425640 and rs188478854. The rare disease signal at rs548877132 carries the highest magnitude score in the dataset. Several additional variants - including rs114018400, rs140093730, rs143445068, rs2625302, rs2625320, rs2707098, and rs79661416 - appear at magnitude 4.50 without a trait label in the current dataset.

Evidence quality

The dataset lists 266 variants in total, with 37 carrying prior research summaries. The editorial summaries for the five variants with published pages (rs114018400, rs11025120, rs10766557, rs10766558, rs11605275) do not include study-level detail in the current input, so effect sizes, sample sizes, and replication status cannot be reported here. Magnitude scores serve as internal evidence-weighting signals; rs548877132 at 5.50 is the strongest, but without cohort data it is not possible to characterize whether this reflects a large multi-cohort GWAS (a genome-wide association study - a scan across many thousands of people's genomes for variants statistically associated with a trait) or a smaller, preliminary finding. All trait assignments in this entry should be treated as provisional pending fuller evidence review.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual. This content does not constitute medical advice, a clinical diagnosis, or a recommendation to take any action.