Expressive

rs11025120 (NAV2): QTc changes in schizophrenia

Key takeaways

  • This SNP is linked to QTc changes in schizophrenia patients taking antipsychotics
  • The effect size reported is 3630 with p=3e-6
  • It also reduces CSRP3 expression in skin sun-exposed lower leg

Key takeaways

  • This SNP is linked to QTc changes in schizophrenia patients taking antipsychotics
  • The effect size reported is 3630 with p=3e-6
  • It also reduces CSRP3 expression in skin sun-exposed lower leg

What the research says This variant is associated with QTc interval changes in schizophrenia patients taking antipsychotics [PMID 29064910]. It also reduces CSRP3 expression in skin sun-exposed lower leg [GTEx].

Reported associations

  • Schizophrenia QTc interval: the variant is associated with increased risk of QTc prolongation in patients taking antipsychotics with a reported effect size of 3630 p=3e-6 [PMID 29064910].

Evidence quality The GWAS involved 661 individuals and reported a strong association with the T allele (p=3e-6) [PMID 29064910]. No other studies in this catalog discuss this variant directly.

Tissue-specific expression effects

  • CSRP3: reduced expression whole blood, aorta, and thyroid [GTEx Portal].

No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Antipsychotic selection with QTc prolongation risk Moderate

    rs11025120-T carriers show greater QTc prolongation during antipsychotic therapy

    Discuss with prescriber when considering or starting antipsychotics

Screening

  • QTc interval during antipsychotic treatment Moderate

    rs11025120-T allele associates with increased QTc prolongation in response to antipsychotics

    Baseline ECG and periodic monitoring if taking antipsychotics

Frequently asked questions

What does the rs11025120 variant do?

It is associated with QTc interval changes in schizophrenia patients taking antipsychotics and it reduces CSRP3 expression in skin sun-exposed lower leg.

Is this SNP linked to schizophrenia?

Yes, the GWAS shows a strong association between the T allele and QTc prolongation in affected individuals.

Does this variant affect gene expression?

It lowers CSRP3 expression specifically in skin sun-exposed lower leg tissue.