OPCML, variants, traits, and what the research shows

OPCML - what this gene does

The variants catalogued for OPCML span several trait themes. Cancer is the dominant theme, appearing across multiple independent variants; secondary themes include mental health, immune function, neurological, cardiovascular, liver, and rare-disease traits.

Key takeaways

• Cancer is the most prominent trait theme, with six catalogued variants in this gene independently linked to cancer phenotypes.
• The highest-magnitude variant on file reaches a score of 5.50 and is linked to cancer.
• Two separate variants carry mental health associations, suggesting a signal distinct from the cancer cluster.
• Additional single-variant associations touch immune function, neurological, cardiovascular, liver, and rare-disease traits.
• All associations are population-level statistical signals from genome-wide studies - not individual predictions.

Notable variants

rs137852691 is the top-ranked variant in this gene (magnitude 5.50) and carries a cancer association. Five further magnitude-4.50 variants share the cancer label: rs1027796, rs117462359, rs187152297, rs549570772, and rs79094382. Outside cancer, rs117402698 and rs7105724 are independently linked to mental health traits, rs138078781 carries an immune association, and rs7117082 is linked to neurological traits.

Trait associations

Cancer is the most internally replicated association theme, with six independent variants - rs137852691, rs1027796, rs117462359, rs187152297, rs549570772, and rs79094382 - all pointing to the same trait category; convergence across multiple independent variants is generally more meaningful than a single isolated hit. Mental health associations appear independently in rs117402698 and rs7105724. The remaining trait categories - immune function (rs138078781), neurological (rs7117082), cardiovascular (rs550829245), liver (rs6421616), and rare disease (rs55669018) - each rest on a single catalogued variant. Several additional variants, including rs117974989, rs12419742, rs2078454, rs4076157, rs6590673, rs73031356, and rs79916885, have magnitude scores on file but no trait labels in the current dataset.

Evidence quality

The dataset contains 122 variants in this gene, 29 with prior research summaries. The top-ranked variants carry magnitudes between 4.50 and 5.50, but specific effect sizes (such as odds ratios or beta coefficients) and study sample sizes are not available in the current dataset for these entries. The cancer signal - supported by six independent variants sharing the same trait label - represents the strongest and most internally consistent association; in GWAS (genome-wide association study - a method that scans many thousands of genomes for variants statistically associated with a trait), convergence across multiple independent signals within the same gene increases confidence relative to a solitary finding. The mental-health, immune, neurological, cardiovascular, liver, and rare-disease associations each rest on a single catalogued variant and should be regarded as more preliminary. Cross-study replication status, population ancestry composition, and whether any signals overlap via linkage disequilibrium (the tendency of nearby variants to be inherited together rather than independently) are not confirmed in the information available here.

What this is NOT

These variants represent population-level statistical associations from genome-wide studies - they are not deterministic predictors of any outcome for any individual, and carrying a given allele does not imply a guaranteed clinical consequence. This entry does not constitute medical advice, a diagnosis, or a recommendation for any action.