NCAM1, variants, traits, and what the research shows

NCAM1 - what this gene does

NCAM1 appears across population-level genetic research in the context of mental health, neurological traits, rare disease, and cancer - the four trait themes represented among the 162 variants catalogued here. No single well-characterised function can be stated beyond what those associations reveal.

Key takeaways

• Mental health is the dominant trait theme - over a dozen variants carry that tag across independent research signals
• The highest-magnitude variant here is tagged to a rare disease, standing a full point above the next tier
• Neurological and cancer signals appear across multiple separate variants
• 162 variants have been catalogued for this gene, with 40 carrying prior published research context
• All associations are population-level statistical signals, not predictions for any individual

Notable variants

The single strongest signal on file is rs2137581837, which carries a magnitude score of 5.50 and is tagged to a rare disease trait - a full point above the next tier. A large cluster at magnitude 4.50 spans mental health and neurological categories: mental health variants in this tier include rs10891495, rs10891496, rs10891510, rs11214447, rs1245133, rs2298527, and rs4444109. Neurological associations appear via rs11214475 and rs2885208. Cancer-linked variants include rs184731128 and rs55643163. Three magnitude-4.50 variants - rs11607273, rs1245101, and rs4424705 - have published pages but no trait label is currently available in this dataset.

Trait associations

Mental health is the most represented trait category: at least twelve distinct variants carry that tag, including rs10891495, rs10891496, rs10891510, rs11214447, rs1245133, rs12577005, rs141881809, rs2298527, rs2509377, rs3781878, rs4439551, and rs4444109. The density of mental health variants across independent rsids suggests GWAS - genome-wide association studies, large scans that compare genetic variants across thousands of people to find statistical links with traits - have repeatedly flagged this region in psychiatric contexts. Neurological trait signals appear separately via rs11214475 and rs2885208. The rare disease signal at rs2137581837 stands apart both in magnitude and trait category. Cancer associations arise at rs184731128 and rs55643163.

Evidence quality

A total of 162 variants are on file, with 40 carrying prior research summaries and 8 having full published editorial pages (rs10891495, rs10891496, rs10891510, rs11214447, rs11214475, rs1245133, rs11607273, rs1245101). Magnitude scores reflect a combination of effect size and evidence strength as scored by the curation pipeline - they are not clinical risk scores. The mental health pattern is the broadest signal in the data, but specific diagnoses, effect sizes, and sample sizes are available only on the individual SNP pages. Any finding from a single cohort should be treated as preliminary until independently replicated.

What this is NOT

The variants listed here are population-level statistical signals - they reflect average differences across large groups, not deterministic predictions for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.