Expressive

rs10891495 (NCAM1): tissue-specific expression changes

Key takeaways

  • This SNP is associated with substance use disorder in a large GWAS study.
  • NCAM1 expression is lower in muscle and esophagus tissue.
  • The expression change is modest but statistically significant.

Key takeaways

  • This SNP is associated with substance use disorder in a large GWAS study.
  • NCAM1 expression is lower in muscle and esophagus tissue.
  • The expression change is modest but statistically significant.

What the research says This SNP is linked to substance use disorder, with an effect allele T showing higher risk in about 1.8 million people 41057643. NCAM1 expression is reduced in muscle and esophagus tissue, with modest but significant decreases GTEx Portal.

Reported associations

  • Substance use disorder: risk allele T associated with higher risk, effect size 6.34 p=1e-10 in ~1.8 million individuals 41057643
  • NCAM1 expression lower in muscle and esophagus tissue, slope -0.25 p=7e-12 [GTEx Portal]

Evidence quality The GWAS study used 1.8 million individuals and reports strong evidence with p=1e-10. The GTEx data shows modest but significant expression changes in muscle and esophagus, but these are tissue-specific and not disease-related. No conflicting findings.

Tissue-specific expression effects

  • NCAM1 expression is lower in muscle and esophagus, higher in adrenal gland and testis [GTEx Portal] Last lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • Substance use disorder screening Moderate

    rs10891495 T allele shows strong genetic association with substance use disorder (p<1e-10 in 1.7M-person study).

    Discuss genetic predisposition and substance use disorder screening with healthcare provider

Frequently asked questions

What does rs10891495 mean?

It is a genetic variant in the NCAM1 gene that has been linked to substance use disorder and affects how much of the protein is made in certain tissues.

Is this variant harmful?

The evidence shows it raises risk for substance use disorder but does not cause disease on its own.

Can I change my expression levels?

No, gene expression changes are a natural biological response and cannot be altered by lifestyle choices.