rs10891510 (NCAM1): linked to smoking initiation
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is linked to smoking initiation and substance use disorder.
- It increases expression of NCAM1 in aorta and skeletal muscle.
- The effect sizes are small but statistically significant.
Key takeaways This variant is linked to smoking initiation and substance use disorder. It increases expression of NCAM1 in aorta and skeletal muscle. The effect sizes are small but statistically significant.
What the research says This variant is associated with smoking initiation PMID 36477530 and substance use disorder PMID 41057643. It also increases expression of NCAM1 in aorta and skeletal muscle.
Reported associations Smoking initiation: the variant is linked to smoking initiation a reported effect size of 0.014 p=7e-57 PMID 36477530 Substance use disorder: the variant is linked to substance use disorder a reported effect size of 5.47 p=4e-8 PMID 41057643
Evidence quality The supplied studies each report distinct trait associations with sample sizes of about 2.7 million and 1.5 million individuals respectively p-values are extremely low indicating strong statistical significance there is no conflict between the two findings.
Tissue-specific expression effects
- NCAM1: increased expression in aorta and skeletal muscle
No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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substance use disorder genetic risk assessment Moderate
NCAM1 variants associate with increased substance use disorder susceptibility.
Discuss risk assessment and prevention strategies
Lifestyle
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smoking initiation Moderate
NCAM1 variant strongly associates with smoking initiation susceptibility.
Frequently asked questions
What does rs10891510 mean?
It is a genetic variant in the NCAM1 gene that has been linked to smoking initiation and substance use disorder.
Is this variant related to cancer?
The studies do not report any association with cancer.