rs10891496 (NCAM1): increases adrenal expression

Key takeaways

• Associated with neuroticism in a large GWAS
• Increases expression in the adrenal gland
• Decreases expression in muscle and skin tissues

What the research says The GWAS Catalog reports that rs10891496 is linked to higher levels of neuroticism with an effect size of 5.93 and a p-value of 3e-9 in about 449 thousand individuals29942085. GTEx expression data show the variant increases NCAM1 expression in the adrenal gland while decreasing it in muscle and skin tissuesGTEx Portal.

Reported associations

• Neuroticism: the variant is associated with higher neuroticism, reported effect size 5.93 p=3e-9 in about 449 thousand individuals29942085

Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog [29942085]. The evidence is strong with large sample size and low p-value. No conflicting findings are present.

Tissue- specific expression effects

• NCAM1: increased expression in adrenal gland, decreased expression in muscle skeletal and skin not sun exposed suprapubicGTEx Portal

Lifestyle considerations No lifestyle considerations on file for this variant.