DAB1, variants, traits, and what the research shows

DAB1 - what this gene does

Variants catalogued in DAB1 (Disabled Homolog 1) cluster around several trait categories - including rare diseases, neurological conditions, liver-related phenotypes, and cancer - making this gene a point of research interest across multiple organ systems.

Key takeaways

• DAB1 variants span rare diseases, neurological conditions, liver phenotypes, and cancer.
• The strongest signals reach magnitude 5.5, tied to rare disease and neurological categories.
• At least four independent variants carry neurological trait labels, suggesting a consistent pattern in that domain.
• Two separate variants point to liver-related traits, indicating a possible hepatic dimension.
• All associations are population-level statistics - no single variant predicts disease with certainty for any individual.

Notable variants

The highest-magnitude signals are rs199793708 and rs570170859 (both magnitude 5.5, rare disease) and rs376587394 (magnitude 5.5, neurological). A magnitude-5.0 neurological variant, rs1646774558, further reinforces the neurological theme. Among the magnitude-4.5 entries, rs116156725 carries a cancer association; rs116417497 and rs61781882 are each linked to liver-related traits; and rs112437613 and rs148267997 contribute additional neurological associations.

Trait associations

The catalogued variants cluster around several distinct themes:

• Rare disease: rs199793708, rs570170859, and rs527409 each carry rare-disease labels at high magnitude.
• Neurological: rs376587394, rs1646774558, rs112437613, and rs148267997 all share neurological trait labels - four independent variants converging on this theme strengthens the signal relative to any single finding.
• Liver: rs116417497 and rs61781882 are both tagged with liver-related traits.
• Cancer: rs116156725 carries a cancer association.
• Mental health and hormonal: rs147333636 is tagged with a mental-health trait; rs72664661 carries a hormonal association.

Evidence quality

The three top-magnitude variants - rs199793708, rs376587394, and rs570170859 - reach magnitude 5.5, suggesting relatively strong effect sizes or statistical confidence in their source datasets; however, rare-disease variants at high magnitude often reflect small, highly selected cohorts rather than large general-population GWAS (genome-wide association studies - scans of many people's genomes for variants statistically linked to traits). Five variants (rs116124269, rs116417497, rs113279853, rs116156725, rs112437613) have separately published research pages, indicating dedicated prior editorial review. With 194 total variants on file and only 34 carrying detailed prior summaries, the majority of entries remain lightly annotated. The neurological association is the most replicated theme, appearing across at least four independent variants - replication across independent signals is a meaningful, though not definitive, indicator of a genuine relationship.

What this is NOT

These variants represent population-level statistical associations, not deterministic predictors of any disease or health outcome for any individual. This content is informational only and does not constitute medical advice, diagnosis, or any recommendation to act.