rs116156725 DAB1 Oligodendroglioma association
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Key takeaways
- rs116156725 is linked to a rare brain tumor with strong evidence
- the variant may increase MYSM1 expression in the esophagus muscularis
- this association is based on a single GWAS study and has limited replication
Key takeaways
- rs116156725 is linked to a rare brain tumor with strong evidence
- the variant may increase MYSM1 expression in the esophagus muscularis
- this association is based on a single GWAS study and has limited replication
What the research says The rs116156725 variant in DAB1 is associated with oligodendroglioma, a rare brain tumor, with an effect size of 11.11 and p=1e-5 in about 7000 individuals PMID 36810956. The GTEx data shows this variant increases MYSM1 expression in the esophagus muscularis, a tissue-specific effect GTEx Portal.
Reported associations Oligodendroglioma: the variant is linked to this rare brain tumor with an effect size of 11.11 and p=1e-5 in about 7000 individuals PMID 36810956.
Evidence quality The evidence comes from a single GWAS study (PMID 36810956) with a sample size of about 7000 individuals, yielding an effect size of 11.11 and p=1e-5. No replication studies are reported in the supplied data, so the association is not confirmed by independent work.
Tissue-specific expression effects
- MYSM1: increased expression Esophagus Muscularis GTEx Portal.
Last lifestyle considerations on file for this variant.