DAB1 variant linked to Alzheimer's risk
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Key takeaways
- DAB1 variant linked to higher Alzheimer's disease risk
- Effect size is an odds ratio of 2.28 with p=5.4e-9
- Found in APOE-ε4 homozygotes only
Key takeaways
- DAB1 variant linked to higher Alzheimer's disease risk
- Effect size is an odds ratio of 2.28 with p=5.4e-9
- Found in APOE-ε4 homozygotes only
What the research says The DAB1 variant rs112437613 is associated with higher Alzheimer's disease risk in APOE-ε4 homozygotes [PMID 35977442].
Reported associations
- DAB1 associated with Alzheimer's disease risk, the reported effect size is an odds ratio of 2.28, p=5.4e-9 [PMID 35977442]
Evidence quality The study used a UK Biobank sample of 288 cases and 5102 controls performing a genome-wide association analysis that identified DAB1 as significant with an odds ratio of 2.28, p=5.4e-9 [PMID 35977442].
No lifestyle considerations on file for this variant.
Frequently asked questions
What does the DAB1 gene do?
The DAB1 gene encodes a protein involved in synaptic regulation and its variant is associated with increased Alzheimer's disease risk.
Is rs112437613 linked to Alzheimer's?
Yes, the variant is associated with higher Alzheimer's disease risk in APOE-ε4 homozygotes.