CNTN5, variants, traits, and what the research shows

CNTN5 - what this gene does

Based on the variants catalogued here, CNTN5 surfaces most prominently in research on rare diseases and neurological conditions, with additional signals spanning mental health, immune function, cancer, sleep, and metabolic traits.

Key takeaways

• The two highest-magnitude variants on file are both linked to rare disease research
• Mental health is the most recurrent trait theme, with five separate variants independently pointing in that direction
• Neurological and immune signals also appear in the dataset
• Effect sizes and replication details are not available for most variants in the current record; all signals should be treated as preliminary
• These are population-level statistical associations, not personal health predictions

Notable variants

The highest-magnitude entries on file - rs200782641 and rs56122118, both scored at 5.50 - are linked to rare disease research and stand above the rest of the dataset. A cluster of mental-health-associated variants follows at magnitude 4.50: rs113262272, rs117557854, rs1690818, rs2510682, and rs61475845 each flag this trait category independently, and convergence across five separate variants is notable. Neurological involvement is represented by rs10790497, immune traits by rs145887885, and cancer associations by rs17134658 and rs74603527. Lone signals also appear for sleep (rs535929585) and metabolic traits (rs549271700).

Trait associations

Rare disease associations carry the highest magnitude scores in this dataset, led by rs200782641 and rs56122118. Mental health is the most frequently represented trait category: five independent variants - rs113262272, rs117557854, rs1690818, rs2510682, and rs61475845 - each appear under this category; multi-variant coverage of the same trait can indicate a more robust signal. Neurological associations are flagged by rs10790497 and immune traits by rs145887885. Cancer associations emerge via rs17134658 and rs74603527, while rs535929585 links to sleep and rs549271700 to metabolic traits. Additional variants - including rs10790768, rs111677020, rs116735839, rs148729293, rs534159225, rs628246, and rs72991567 - appear in the dataset but lack trait labels in the current version of this record.

Evidence quality

Of the 221 variants on file, 42 carry prior research summaries. Detailed effect sizes (such as odds ratios or beta coefficients) and study sample sizes are not available in the current dataset for the top-ranked entries, limiting how firmly any individual signal can be assessed. The two rare-disease variants at magnitude 5.50 likely reflect higher-penetrance findings rather than typical common GWAS (genome-wide association study - a scan across tens or hundreds of thousands of genomes to detect variants statistically linked to a trait) signals, though this cannot be confirmed without underlying study data. The five-variant mental-health cluster is suggestive of a real signal, but independent replication across separate cohorts is not documented here, and single-cohort findings carry more uncertainty. All findings should be considered preliminary until fuller study-level metadata is available.

What this is NOT

These variants represent population-level statistical signals derived from group studies - they do not predict any individual's health outcomes or traits. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.