Expressive

rs117557854 (CNTN5): linked to alcohol dependence

Key takeaways

  • This variant is linked to alcohol dependence
  • The effect size is 2.08 p=2e-6 in about 15 thousand people
  • The risk allele A is associated with higher risk

Key takeaways

  • This variant is linked to alcohol dependence
  • The effect size is 2.08 p=2e-6 in about 15 thousand people
  • The risk allele A is associated with higher risk

What the research says This variant is associated with alcohol dependence with a reported effect size of 2.08 p=2e-6 in about 15 thousand individuals [PMID 26365420].

Reported associations Alcohol dependence The variant is associated with alcohol dependence with a reported effect size of 2.08 p=2e-6 in about 15 thousand individuals [PMID 26365420].

Evidence quality The supplied studies describe an association between rs117557854 and alcohol dependence based on a genome-wide association study of about 15 thousand individuals with effect size 2.08 p=2e-6 [PMID 26365420]. The risk allele A is linked to higher risk.

Lifestyle considerations

  • alcohol (lifestyle, limit): carriers tend to consume more alcohol

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Alcohol dependence risk and family history Moderate

    CNTN5 genetic association with alcohol dependence warrants clinical assessment of risk and preventive strategies

    Inform clinician of this variant; review family history of substance use disorders

Lifestyle

  • Alcohol moderation or abstinence Moderate

    Genetic association with alcohol dependence suggests heightened vulnerability to problematic drinking

    If drinking: women limit to less than 7 drinks per week, men less than 14; abstinence is safest

Screening

  • Alcohol consumption patterns Moderate

    CNTN5 variant associated with increased alcohol dependence risk; monitoring enables early detection of problematic use

    Track frequency and quantity; consider AUDIT-C screening annually

Frequently asked questions

What does rs117557854 mean?

It is a genetic variant in the CNTN5 gene that has been linked to alcohol dependence based on a genome-wide association study.

Is this variant harmful?

The evidence shows an association with higher risk of alcohol dependence but does not indicate harm or benefit for individuals.

Can I change my drinking because of this?

No the study only describes a link and does not recommend any changes.