rs111677020 - CNTN5 protein and gut microbiome link

Key takeaways

• rs111677020 is linked to higher CNTN5 protein levels
• the variant also influences gut microbiome composition
• both findings are based on large GWAS studies

What the research says This variant is associated with higher CNTN5 protein levels PMID 39789286 and influences gut microbiome abundance PMID 40187613. The effect sizes are small to moderate.

Reported associations

• CNTN5 protein levels: the variant is associated with higher protein levels, reported effect size 0.077 p=9e-31 in about 47 thousand individuals PMID 39789286
• Gut microbiome abundance: the variant is associated with higher Blautia sp. 9 abundance at one year, interacting with spring birth, reported effect size 1.59 p=4e-9 in about 688 individuals PMID 40187613

Evidence quality The supplied studies are both GWAS Catalog associations with large sample sizes, one of 47 thousand and the other 688 individuals, yielding very low p-values indicating strong statistical significance. No conflicting findings were reported. No lifestyle considerations on file for this variant.