SORCS3, variants, traits, and what the research shows

SORCS3 - what this gene does

SORCS3 (Sortilin-related VPS10 domain-containing receptor 3, sometimes listed by its chromosomal neighbourhood on 10q25) surfaces in population-level genomic research most consistently in the context of mental health, with additional signals on record for neurological and cardiovascular trait categories.

Key takeaways

• Five of the highest-priority variants catalogued for this gene are each independently associated with mental health traits.
• Separate variants link the gene to neurological and cardiovascular phenotypes.
• All 160 catalogued variants are population-level statistical associations - not individual health predictions.
• The mental health signal is the most internally consistent finding, appearing across five distinct variant sites.
• Full effect-size and cohort replication details are not yet available for several entries.

Notable variants

Five magnitude-4.50 variants - rs11192230, rs11192260, rs11599236, rs11599313, and rs7074335 - are each flagged for mental health associations and share the highest priority score on file, a cluster that lends more weight to the mental health signal than any single finding would. A neurological association is recorded for rs117792039, and a cardiovascular association for rs547513244, both also at magnitude 4.50. Two additional magnitude-4.50 variants - rs1475762 and rs184389714 - are catalogued without an assigned trait label at this time.

Trait associations

Mental health is the most represented trait theme: five distinct variants (rs11192230, rs11192260, rs11599236, rs11599313, rs7074335) each carrying the top magnitude score all point in this direction. Recurrence across multiple independent loci is generally considered a stronger signal than a single-variant finding. Neurological traits appear through rs117792039, and cardiovascular traits through rs547513244.

Evidence quality

All nine top-tier variants reach magnitude 4.50, the highest score visible in this catalogue, reflecting a combination of effect-size estimates and evidence-strength weighting; the mental health association is the most internally replicated, appearing across five separate variant sites rather than just one. A further tranche of magnitude-3.00 variants extends the total catalogue to 160 entries. Detailed per-variant data - including GWAS (genome-wide association study: a design that scans genetic markers across hundreds of thousands of people to find variants statistically linked to a trait) cohort sizes, odds ratios, and independent replication-cohort information - are not yet surfaced in the available summaries, so precise confidence levels for individual signals cannot be fully assessed from the information currently on hand.

What this is NOT

Every variant listed here is a population-level statistical association identified across large groups of people and does not predict any individual's health, traits, or outcomes with certainty. Nothing on this page constitutes a diagnosis, prescription, or recommendation of any kind.