rs11599313 SORCS3 neurobehavioral link
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Key takeaways
- rs11599313 is linked to neuropsychiatric conditions with a strong effect
- It also relates to attention-deficit hyperactivity disorder and risk taking behavior
- The variant increases expression in pituitary and brain reward regions
Key takeaways
- rs11599313 is linked to neuropsychiatric conditions with a strong effect
- It also relates to attention deficit hyperactivity disorder and risk taking behavior
- The variant increases expression in pituitary and brain reward regions
What the research says This variant is associated with neuropsychiatric disorders, reported effect size 5.89 p=4e-9 in about 728 thousand individuals, risk allele T.[33479212] It also links to attention deficit hyperactivity disorder and risk-taking behavior, p=5e-9 in about 730 thousand individuals.[38565336]
Reported associations Neuropsychiatric disorders - the variant is linked to these conditions with a reported effect size of 5.89 and p=4e-9 in about 728 thousand individuals.[33479212] Attention deficit hyperactivity disorder or risk-taking behavior - the variant is linked to these traits with a reported effect size of 5.0 and p=5e-9 in about 730 thousand individuals.[38565336]
Evidence quality The supplied studies are genome-wide association study results from the GWAS Catalog. Each reports a strong association with a neuropsychiatric trait or behavior using large samples of roughly 730 thousand people and p-values below 1e-8. No conflicting findings were reported for this variant across the two studies.
Tissue-specific expression effects
- SORCS3: increased expression in whole blood, pituitary, and brain nucleus accumbens basal ganglia.GTEx Portal
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11599313 mean?
It is a genetic change in the SORCS3 gene that has been linked to neuropsychiatric conditions and attention-deficit hyperactivity disorder.
Is this variant harmful?
The studies show it is associated with certain traits but do not indicate any health risk or benefit for individuals.
Does it affect brain function?
Yes, the variant increases expression in pituitary tissue and brain regions involved in reward.