rs11192260 (SORCS3): PTSD risk
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Key takeaways
- This variant is linked to post-traumatic stress disorder with a reported effect size of 5.57 and p=3e-8 in about 1.3 million people.
- The allele increases expression of SORCS3 in pituitary tissue.
- No other traits or genes are associated with this variant.
Key takeaways
- This variant is linked to post-traumatic stress disorder with a reported effect size of 5.57 and p=3e-8 in about 1.3 million people [PMID 38637617].
- The allele increases expression of SORCS3 in pituitary tissue GTEx Portal.
- No other traits or genes are associated with this variant.
What the research says This GWAS Catalog association links rs11192260 to post-traumatic stress disorder [PMID 38637617]. The variant is associated with a risk allele T and has an effect size of 5.57 p=3e-8 in about 1.3 million individuals.
Reported associations
- Post-traumatic stress disorder: the variant increases risk with effect size 5.57 p=3e-8 [PMID 38637617].
- SORCS3 expression: increased expression in pituitary tissue GTEx Portal.
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association [PMID 38637617]. No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11192260 mean?
rs11192260 is a genetic variant that increases the risk of post-traumatic stress disorder and raises SORCS3 expression in the pituitary.