RFLNA, variants, traits, and what the research shows

RFLNA - what this gene does

RFLNA is a human gene whose catalogued variants show statistical associations - predominantly from genome-wide association studies (GWAS - studies that scan many people's genomes for variants statistically linked to a trait) - spanning cancer, metabolic, hormonal, cardiovascular, and kidney-related trait domains. No functional mechanism can be stated from the available data; the description below reflects trait signals observed in population-level research.

Key takeaways

• RFLNA variants have been statistically linked to cancer, metabolic, hormonal, cardiovascular, and kidney-related traits.
• Six variants share the highest evidence-weighted scores in this dataset, including one cancer-linked and one metabolic-linked signal.
• Metabolic associations appear across five separate variant entries - the most frequently repeated trait theme in this gene's data.
• 151 total variants are on file; 45 have published research summaries.
• These are population-level signals, not individual health predictions.

Notable variants

The six variants with the highest magnitude scores (4.50) in this dataset are rs117822075, rs142973841, rs183910463, rs192295131, rs427244, and rs7969148. Of these, rs117822075 carries a cancer trait label and rs183910463 a metabolic trait label; trait metadata for the remaining four is not yet available. At the next evidence tier (magnitude 2.80), rs116909606 and rs190618143 appear. Among the magnitude-2.20 entries, rs10606185 is associated with a hormonal trait, rs10773049 with a cardiovascular trait, and rs10773051 with a kidney-related trait.

Trait associations

Five trait domains are represented across the catalogued variants. Cancer: flagged for rs117822075, the single highest-magnitude entry with a named trait. Metabolic: the most-replicated theme, appearing for rs183910463, rs10773052, rs10773054, rs10846592, and rs10846606 - five independent entries, which adds weight to the signal compared to any single observation. Hormonal: represented by rs10606185. Cardiovascular: represented by rs10773049. Kidney: represented by rs10773051. Several high-magnitude variants carry no trait label in current metadata and remain incompletely characterized.

Evidence quality

With 151 variants on file and 45 carrying published research summaries, this gene has a moderately dense evidence footprint. The metabolic signal is the most broadly supported, appearing across five separate variant entries rather than a single observation - multiple independent signals pointing to the same trait domain increase confidence, though detailed study-level metrics such as odds ratios, beta coefficients, sample sizes, and replication status are not available in the current dataset. The highest-magnitude tier (4.50) includes one cancer-linked and one metabolic-linked variant alongside four with no trait labels, limiting full characterization of those signals. Treat all associations here as hypothesis-generating observations pending further validation.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors of any individual's health or disease risk. Nothing on this page constitutes medical advice, a clinical diagnosis, or a recommendation to take or avoid any action.