rs10846585 - RFLNA: linked to higher metabolite levels
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Key takeaways
- rs10846585 is associated with higher metabolite levels
- The variant reduces expression of TCTN2 in the Esophagus Muscularis
- ZNF664 expression increases in Nerve Tibial, Esophagus Muscularis and Adipose Subcutaneous
Key takeaways rs10846585 is associated with higher metabolite levels. The variant reduces expression of TCTN2 in the Esophagus Muscularis and increases expression of ZNF664 in Nerve Tibial, Esophagus Muscularis and Adipose Subcutaneous.
What the research says rs10846585 is associated with higher metabolite levels a reported effect size of 0.32 p=3e-6 in about 2 thousand individuals [PMID 23823483].
Reported associations Metabolite levels: the variant is associated with higher metabolite levels a reported effect size of 0.32, p=3e-6, in about 2 thousand individuals [PMID 23823483].
Evidence quality The GWAS Catalog study reports an association between rs10846585 and Metabolite levels with a reported effect size of 0.32, p=3e-6 in about 2 thousand individuals [PMID 23823483]. No replication data provided; this is the only source.
Tissue-specific expression effects
- TCTN2: reduced expression in Esophagus Muscularis GTEx Portal
- ZNF664: increased expression in Nerve Tibial, Esophagus Muscularis, Adipose Subcutaneous GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10846585 mean?
It is a genetic variant in the RFLNA gene that has been linked to higher levels of certain metabolites and influences the expression of TCTN2 and ZNF664 in specific tissues.
Is this variant harmful?
The evidence shows only an association with metabolite levels; no direct health risk or benefit is reported.
Can I change my diet based on this?
There are no dietary recommendations tied to this variant; it does not suggest any lifestyle changes.