PKN2-AS1, variants, traits, and what the research shows

PKN2-AS1 - what this gene does

PKN2-AS1 is a gene whose catalogued variants span several trait domains; based on the variants on file, the clearest recurring themes are cardiovascular health, liver function, respiratory conditions, neurological traits, mental health, sleep, and cancer.

Key takeaways

• Five separate variants are independently linked to cardiovascular health, making it the strongest and most repeated theme in this gene's dataset.
• Liver function appears across three variants, suggesting a consistent secondary association.
• Single-variant signals also connect this gene to respiratory conditions, neurological traits, mental health, sleep, and cancer.
• All associations come from population-level genome-wide studies - statistical patterns in large groups, not individual predictions.
• The evidence base is actively growing: 157 variants have been catalogued, with 36 carrying prior research summaries.

Notable variants

Five cardiovascular-linked variants stand out for their clustering: rs12032672, rs181100621, rs1846413, rs1960306, and rs6698723 all sit at magnitude 4.50, the highest tier in this dataset. On the liver side, rs12145922 and rs77285343 also reach magnitude 4.50, while rs1002436 carries a liver association at the lower magnitude of 2.20. rs115982800 is flagged for respiratory traits and rs17130142 for cancer, each at magnitude 4.50. Neurological associations appear in rs35214987 and rs6658799.

Trait associations

Cardiovascular phenotypes represent the most prominent theme: five separate variants - rs12032672, rs181100621, rs1846413, rs1960306, and rs6698723 - are all independently flagged in this domain, and multi-variant convergence on a single trait strengthens the overall signal. Liver-related traits follow, with rs12145922, rs77285343, and rs1002436 each carrying liver-trait labels. Additional single-variant signals span respiratory conditions (rs115982800), cancer (rs17130142), neurological traits (rs35214987 and rs6658799), mental health (rs2207285), and sleep (rs306336).

Evidence quality

Nearly all highlighted variants score at magnitude 4.50 - the highest tier in this dataset - with one exception: rs1002436 at 2.20, a lower evidence level. Six variants have dedicated published pages (rs12032672, rs10754321, rs10801903, rs115982800, rs12145922, rs1002436), reflecting a more developed record for those loci. The full gene catalog spans 157 variants with 36 carrying prior research summaries, indicating an active but still-developing body of literature. All associations derive from GWAS - genome-wide association studies, which scan hundreds of thousands of genetic variants across large populations for statistical links to traits. Specific effect sizes, sample sizes, and replication details are not yet available in this summary; individual variant pages will carry that depth when populated, and without it the relative strength of each association cannot be fully ranked.

What this is NOT

These variants are population-level statistical signals from large genomic studies - they describe tendencies across groups and do not predict any outcome for an individual. This page does not prescribe, diagnose, or advise any course of action.