rs10754321 (PKN2-AS1): higher MCP1 levels
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Key takeaways
- This variant is linked to higher MCP1 protein amounts
- The gene PKN2 shows increased expression in colon tissue
- The effect on MCP1 is statistically significant
Key takeaways This variant is linked to higher MCP1 protein amounts The gene PKN2 shows increased expression in colon tissue The effect on MCP1 is statistically significant
What the research says A genome-wide association study found that rs10754321 is associated with higher levels of MCP1 a protein involved in cell signaling with an effect size of 4.52 and p=6e-6 in 359 participants [PMID 38326779]. The variant also shows increased expression of the PKN2 gene in colon tissue GTEx Portal.
Reported associations
- MCP1 levels the variant is linked to higher protein amounts a reported effect size of 4.52 p=6e-6 in about 359 people [PMID 38326779].
Evidence quality The GWAS used a sample of 359 individuals and reported a significant association with MCP1 levels (p=6e-6). No other studies in the catalog discuss this variant directly.
Tissue-specific expression effects
- PKN2: increased expression in colon tissue GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10754321 do?
It is linked to higher MCP1 protein amounts and the gene PKN2 shows increased expression in colon tissue.
Is this variant related to any disease?
The GWAS found a significant association with MCP1 levels but no direct disease link was reported.
Can I test for this variant?
Yes it is catalogued as rs10754321 and can be ordered through standard genetic testing services.