rs12032672 PKN2-AS1 linked to periodontitis and blood pressure
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Key takeaways
- This variant is linked to periodontal health.
- It may influence systolic blood pressure.
- The effect size for periodontitis is 1.99 with p=1e-6 in about 1000 people.
- The effect size for blood pressure is a strong association with p=3e-8 in over 422 thousand individuals.
- No direct disease phenotype is reported.
Key takeaways
- This variant is linked to periodontal health.
- It may influence systolic blood pressure.
- The effect size for periodontitis is 1.99 with p=1e-6 in about 1000 people.
- The effect size for blood pressure is a strong association with p=3e-8 in over 422 thousand individuals.
- No direct disease phenotype is reported.
What the research says This variant is associated with periodontal microbiota PMID 22699663. It is also linked to systolic blood pressure PMID 30595370.
Reported associations
- Periodontal microbiota: the variant C allele is associated with higher risk, reported effect size 1.99 p=1e-6 in about 1 thousand individuals PMID 22699663.
- Systolic blood pressure: the variant is associated with lower risk, reported effect size p=3e-8 in about 422 thousand individuals PMID 30595370.
Evidence quality The evidence comes from two genome-wide association study catalog entries with large sample sizes and very low p-values indicating strong statistical significance. No direct disease phenotype is reported for this variant.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12032672 do?
It is a genetic variant at the PKN2 gene that may influence periodontal health and blood pressure based on GWAS data.
Is this variant linked to disease?
The studies show associations with periodontal microbiota and systolic blood pressure but no direct disease phenotype is reported.
How strong are the effects?
The effect size for periodontitis is 1.99 p=1e-6 in about 1000 people, while the blood pressure association has a very low p-value of 3e-8 in over 422 thousand individuals.