NEGR1, variants, traits, and what the research shows

NEGR1 - what this gene does

Variants catalogued for NEGR1 span four trait domains - neurological, cardiovascular, mental health, and immune - making it one of the more broadly associated genes in this dataset. Specific biological mechanisms are not derivable from variant-level data alone, but the distribution of high-priority signals across these categories points to potential relevance in multiple physiological systems.

Key takeaways

• Five high-magnitude variants in this gene are linked to neurological traits - the most represented category in this dataset
• Two variants carry cardiovascular associations
• Three independent variants are linked to mental health traits, a degree of within-gene replication that modestly strengthens that signal
• An immune-related association is also catalogued
• All signals here are population-level statistics, not individual health predictions

Notable variants

Fourteen variants reach the highest priority tier (magnitude 4.50). The neurological signals include rs11587895 and rs4348675, both linked to neurological traits; rs12137936 sits at the same tier and has a published page. Cardiovascular associations are carried by rs11209878 and rs6678735. Three independent mental health associations - rs1486091, rs1870676, and rs9424976 - appear within the same gene, a noteworthy concentration for a single locus. rs138840863 rounds out the tier with an immune association.

Trait associations

Neurological traits show the broadest representation: rs11587895, rs12564885, rs4348675, rs67474621, and rs77944304 are each linked to this domain - five independent hits at the top magnitude tier. Cardiovascular associations appear for rs11209878 and rs6678735. Mental health traits are represented by rs1486091, rs1870676, and rs9424976; three independent variants sharing a trait category within one gene is a modestly stronger pattern than a single GWAS hit. rs138840863 carries an immune association. Two additional high-magnitude variants, rs375435036 and rs72941254, are catalogued without a trait label in the current dataset.

Evidence quality

Of the 122 variants on file, 40 carry prior research summaries; the 14 highest-priority signals all sit at magnitude 4.50. These represent GWAS (genome-wide association study - a research design that scans large populations for genetic variants statistically linked to a trait) signals, which describe population-level tendencies rather than individual outcomes. Specific effect sizes, odds ratios, and cohort details are not available in the current dataset. Three variants - rs11587895, rs12137936, and rs11209878 - have published pages, though their detailed editorial summaries were not available at time of writing, limiting the granularity of this entry. Lower-magnitude variants such as rs140517365 and rs151324323 (magnitude 3.00) represent weaker or more preliminary signals and warrant additional caution.

What this is NOT

These variants are population-level statistical signals drawn from large genome scans - they do not determine or predict health outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.