rs12137936 (NEGR1): linked to mood swings and depression
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs12137936 is a common variant near the NEGR1 gene.
- The C allele is linked to mood swings with strong evidence.
- The G allele is linked to depressed affect with moderate effect.
- NEGR1 expression rises in nerve tissue.
Key takeaways
- rs12137936 is a common variant near the NEGR1 gene.
- The C allele is linked to mood swings with strong evidence.
- The G allele is linked to depressed affect with moderate effect.
- NEGR1 expression rises in nerve tissue.
What the research says The C allele is associated with mood swings, reported effect size 6.06 p=1e-9 in about 373 thousand individuals [29500382]. The G allele is associated with depressed affect, reported effect size 0.014 p=3e-8 in about 357 thousand individuals [29942085].
Reported associations Mood swings: the C allele is linked to this trait with a reported effect size of 6.06 p=1e-9 in about 373 thousand individuals [29500382]. Depressed affect: the G allele is linked to this trait with a reported effect size of 0.014 p=3e-8 in about 357 thousand individuals [29942085].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via 29500382 and 29942085. Both GWAS have large sample sizes and low p-values indicating strong evidence. GTEx shows increased NEGR1 expression in nerve_tibial [GTEx].
Tissue-specific expression effects
- NEGR1: increased expression in nerve_tibial [GTEx]
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12137936 do?
It is a common variant near the NEGR1 gene that has been linked to mood swings and depression risk depending on which allele you carry.
Is this variant related to brain function?
Yes it influences expression in nerve tissue according to GTEx data.
Can I change my risk with lifestyle?
There is no evidence linking the variant to lifestyle changes that alter mood or depression.