rs11587895 (NEGR1): intelligence association
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is linked to intelligence with a reported effect size of 7 and p=3e-12 in about 269 thousand individuals
- The allele increases expression of the gene in brain cerebellum and nerve tibial tissue
- Expression also rises in visceral fat tissue
Key takeaways
- This variant is linked to intelligence with a reported effect size of 7 and p=3e-12 in about 269 thousand individuals
- The allele increases expression of the gene in brain cerebellum and nerve tibial tissue
- Expression also rises in visceral fat tissue
- No lifestyle considerations are currently associated
What the research says This variant is associated with intelligence [PMID 29942086]. The GTEx data show increased expression of NEGR1 in Brain_Cerebellum and Brain_Cerebellar_Hemisphere [GTEx] and in Nerve_Tibial [GTEx] and Adipose_Visceral_Omentum [GTEx].
Reported associations
- Intelligence: the variant is associated with intelligence a reported effect size of 7 p=3e-12 in about 269 thousand individuals [PMID 29942086].
- Expression: increased expression in Brain_Cerebellum and Brain_Cerebellar_Hemisphere Nerve_Tibial Adipose_Visceral_Omentum [GTEx].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association. The effect size is 7 p=3e-12 sample size about 269 thousand individuals.
**- NEGR1: increased expression in Brain_Cerebellum and Brain_Cerebellar_Hemisphere Nerve_Tibial Adipose_Visceral_Omentum GTEx Portal.
Frequently asked questions
What does rs11587895 mean?
rs11587895 is a genetic change in the NEGR1 gene that has been associated with higher intelligence scores and increased expression of the gene.
Is this variant related to health problems?
The evidence shows no direct link to disease; it is mainly noted for its association with intelligence and its effect on gene expression in specific tissues.
Can I change my lifestyle because of this variant?
There are currently no lifestyle recommendations tied to this variant, so no changes are advised.