LRMDA, variants, traits, and what the research shows

LRMDA - what this gene does

The variants catalogued for LRMDA cluster most prominently around rare disease phenotypes, with additional associations in cancer, neurological, and mental health conditions.

Key takeaways

• Nine independent variants all reach the highest magnitude tier (5.50), all linked to rare disease - a notable convergence of signals.
• Four more variants at magnitude 5.00 reinforce the rare disease theme, reducing the likelihood this reflects a single-variant artefact.
• Separate variants carry preliminary links to cancer, neurological conditions, and mental health.
• All associations are population-level statistical signals from genetic research, not personal health forecasts.
• Over 200 variants are catalogued in this gene, with dozens backed by published research.

Notable variants

The highest-magnitude signals share a rare disease trait label: rs146123023, rs147768808, rs149792982, rs1564576117, rs1840809914, rs565236615, rs587776953, rs779169360, and rs886043155 all reach magnitude 5.50. A second tier of rare disease variants - rs2492796553, rs587776952, rs769661892, and rs878854351 - registers at magnitude 5.00. Among lower-magnitude findings, rs10509373 links to cancer, rs117082223 to neurological conditions, and rs1124372 to mental health, each at magnitude 4.50.

Trait associations

Rare disease is the dominant theme: thirteen variants spanning two magnitude tiers - nine at 5.50 (including rs146123023, rs565236615, and rs886043155) and four at 5.00 (including rs587776952 and rs878854351) - all carry this label, and the cross-tier replication strengthens the overall signal. Cancer (rs10509373), neurological conditions (rs117082223), and mental health (rs1124372) each appear through a single variant at magnitude 4.50. Four additional magnitude-4.50 variants - rs11001586, rs11001589, rs111307316, and rs12253878 - have published research pages, though their specific trait details are not available in the current summary data.

Evidence quality

The rare disease signal is the most compelling aspect of the evidence base: nine independent variants at the peak magnitude tier, corroborated by four more at 5.00, reflects meaningful convergence rather than a single-variant curiosity - GWAS (genome-wide association studies, which scan many people's genomes for variants statistically linked to a trait) typically regard multi-variant replication within a gene as a stronger signal than an isolated hit. The cancer, mental health, and neurological associations each rest on a single catalogued variant at magnitude 4.50 and should be treated as preliminary pending independent replication. Specific quantitative measures - odds ratios, beta coefficients, or cohort sizes - are not available in the current variant data, limiting precise characterisation of individual effect sizes.

What this is NOT

These variants are population-level statistical associations from genetic research, not deterministic predictors of any individual's health outcomes. Nothing on this page constitutes medical advice, a clinical diagnosis, or a recommendation to take any action.