rs11001586 - LRMDA: vaginal microbiome link
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Key takeaways
- This variant is linked to vaginal microbiome presence with an effect size of 2.62 p=3e-6.
- The allele A is associated with higher levels of the strain Prevotella timonensis.
- Evidence comes from a single GWAS catalog association.
Key takeaways
- This variant is linked to vaginal microbiome presence with an effect size of 2.62 p=3e-6.
- The allele A is associated with higher levels of the strain Prevotella timonensis.
- Evidence comes from a single GWAS catalog association.
What the research says This variant rs11001586 at the LRMDA locus is associated with vaginal microbiome presence specifically the strain s_Prevotella timonensis [PMID 34282934]. The effect size reported is 2.62 p=3e-6.
Reported associations
- Vaginal microbiome presence (s_Prevotella timonensis) - this variant increases the likelihood of having this strain with an effect size of 2.62 p=3e-6 in about 315 individuals [PMID 34282934].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association [PMID 34282934]. The evidence is limited to a single case series with small sample size.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11001586 mean?
rs11001586 is a genetic change at the LRMDA locus that has been linked to higher presence of a vaginal bacteria strain called Prevotella timonensis according to one study.
Is this variant harmful or beneficial?
The association does not indicate harm or benefit it simply shows a statistical link between the allele and the bacterial strain.
Can I change my risk?
No specific advice is given the variant is described only as linked to the strain with small effect size.