rs111307316 - LRMDA: Complement factor H-2 link
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Key takeaways
- rs111307316 is linked to higher Complement factor H-2 levels
- this variant shows a small increase in gene expression in artery and tibial tissues
- the effect size is 6.8 with p=2e-6
Key takeaways
- rs111307316 is linked to higher Complement factor H-2 levels
- this variant shows a small increase in gene expression in artery and tibial tissues
- the effect size is 6.8 with p=2e-6
What the research says This variant is associated with Complement factor H-2 levels, reported effect size 6.8, p=2e-6, in 252 individuals [34260948]. The GTEx data shows increased expression of this gene in artery and tibial tissues [GTEx].
Reported associations
- Complement factor H-2 levels: the variant is associated with higher levels of this protein, reported effect size 6.8 p=2e-6 in about 252 individuals [34260948].
Evidence quality The GWAS used 252 participants and found a strong association with Complement factor H-2 levels (p=2e-6) [34260948]. The GTEx expression data is from 953 donors, showing increased expression in artery and tibial tissues [GTEx].
Tissue-specific expression effects
- SAMD8: increased expression in artery and tibial GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs111307316 do?
rs111307316 is a genetic variant that tends to be found with higher levels of Complement factor H-2 protein and leads to slightly higher expression of the associated gene in artery and tibial tissues.
Is rs111307316 linked to disease?
The study does not link this variant to any specific disease; it is only associated with protein levels and tissue expression.
Can I change my risk?
No, the evidence does not suggest that changing lifestyle can alter the effect of rs111307316 on Complement factor H-2 or gene expression.