LINC03142, variants, traits, and what the research shows

LINC03142 - what this gene does

LINC03142 is a gene whose catalogued variants cluster around neurological and mental health trait categories in population-level genetic research. Additional signals span immune, metabolic, and cancer trait domains, making this a broadly represented locus in the current dataset.

Key takeaways

• Variants near this gene appear most frequently in neurological and mental health trait studies.
• Five separate mental health-linked variants are on file, giving that category the widest representation.
• Immune, metabolic, and cancer trait signals are also present, each covered by multiple independent variants.
• All top-ranked variants share a consistent magnitude score of 4.50 - a uniform signal tier across the gene.
• These are population-level statistical associations, not individual health predictions.

Notable variants

The best-anchored signals are three neurological-category variants with published research pages: rs10965787, rs11794152, and rs11999669, all at magnitude 4.50. A fourth neurological signal, rs1330158, adds further coverage of that domain. On the mental health side, five independent variants - rs10811883, rs12554512, rs17836155, rs4526443, and rs4977846 - collectively make mental health the most numerically represented trait category in this dataset. Immune-associated variants rs187168567 and rs7871386, along with metabolic variants rs72703546 and rs77850702, round out the top-tier catalogue.

Trait associations

This gene's variant data spans five broad trait categories. Neurological associations appear at rs10965787, rs11794152, rs11999669, and rs1330158 - four distinct variants pointing to the same domain, which adds weight to the neurological signal. Mental health associations are the most numerous, with five separate variants (rs10811883, rs12554512, rs17836155, rs4526443, rs4977846) each independently linked to this category. Immune-related signals appear at rs187168567 and rs7871386; metabolic signals at rs72703546 and rs77850702; and a single cancer-category variant at rs190319432.

Evidence quality

All 20 highest-ranked variants carry an identical magnitude score of 4.50, indicating a consistent signal tier rather than a single dominant association. Three neurological variants - rs10965787, rs11794152, and rs11999669 - have published research pages, providing a modest anchor for that trait domain. Specific effect sizes such as odds ratios or beta coefficients, study sample sizes, and replication cohort details are not available in the current summary data, so the relative strength of individual associations cannot be ranked further. The spread of signals across five trait domains could reflect a pleiotropic gene (one influencing multiple traits) or a locus in linkage disequilibrium (statistical co-inheritance) with several functionally distinct nearby variants. All findings should be treated as preliminary until full study-level metadata is reviewed.

What this is NOT

These variants represent population-level statistical signals from genome-wide association studies (GWAS - studies that scan many people's genomes for variants statistically linked to traits), not deterministic predictors of any individual's health or characteristics. This entry does not prescribe, diagnose, or advise any medical or lifestyle action.